Through out the game, the quest log will be capped to 20 many times. The guide makes use of maximizing the total amount of quests you can accept at once. Because of this it is important to follow the guide exactly and only accept quests if the guide tells you to so you won't run into issues not being able to accept a quest. If you do accept a quest that is not listed in the guide, write it down because you may need to abandon it in order to keep following the guide if your quest log is full.
They seem to have expected some things, though, see adding pets with aquatic damage (gun and ooze) aswell as a resistant cockroach to stop us from cheesing everything with elementals. Yet, a fact their damage output is low combined with shields not checking for racial damage means this mechanic prevents a lot as you mentioned. The last boss has got an ability to remove basic shields so perhaps that was not in oblivion either… unlike the reactive damage. Also, an ability that forces swap altogether with an ability which prevents from being swapped, including critters? I can't say I like it.